If you’re taking a GLP-1 weight loss medication like semaglutide, you may notice changes in your appetite, energy, and even the scale. But as your body begins to transform, it’s normal to wonder how those physical changes might affect other parts of your routine, including aesthetic treatments. One common concern for people using both semaglutide and Botox is whether weight loss medications affect the way injectables work.
Here’s what we know (and don’t know) based on expert insight, patient experiences, and the latest available info, plus a few helpful tips for managing your look as your body changes.
Let’s Start with the Basics: Do GLP-1s Chemically Interact with Injectables?
Right now, there’s no clinical evidence that GLP-1 medications like semaglutide chemically interact with Botox or fillers. These are entirely different types of treatments:
- GLP-1s work systemically to regulate appetite and blood sugar.
- Botox is a neuromodulator that temporarily relaxes facial muscles to smooth fine lines.
- Dermal fillers are hyaluronic acid-based gels injected to add volume.
So if you’re wondering whether semaglutide will make your Botox ineffective or “cancel out” your filler, the answer is no. But that doesn’t mean you won’t notice changes.
Why Weight Loss Can Change the Way Fillers Look
If you’re losing weight (especially at a consistent pace), you may start to see changes in your face, including where your fillers sit. That’s because volume loss in the face is a normal part of both aging and fat loss. For some people, it can make cheeks or under-eye areas appear more hollow or “sunken,” even if filler was previously placed there.
This doesn’t mean the fillers stopped working. It just means your facial structure is shifting, and your injectables may need adjusting.
How to Adjust Fillers While Taking GLP-1s
- Check in with your injector: If you notice your filler looks different, a minor touch-up can help restore balance.
- Be patient with the process: Your face may change slowly over time as you lose weight. Small tweaks along the way are more effective than major overhauls.
Does Semaglutide Shorten Botox Results?
There’s no evidence that semaglutide interferes with Botox or other wrinkle relaxers like Dysport, Xeomin, or Daxxify. However, some women report that their usual Botox isn’t lasting as long while on GLP-1 medications.
Is it real? Maybe. But it’s not fully understood yet.
What You Can Do
If you’re finding your results don’t last as long, or just aren’t hitting the same, talk to your injector about switching brands. Each neuromodulator has a slightly different formulation, and your provider might suggest adjusting the product or dosage to achieve the best effect.
Tips to Maintain Your Look While Losing Weight on GLP-1 Medications
During your weight loss journey, you may notice subtle changes in your facial features, and that’s completely normal. It simply means your facial structure is evolving, and a few small adjustments to your beauty routine or injectable schedule may help you maintain the refreshed, balanced look you love.
Here’s how to stay ahead of the curve while feeling confident:
1. Check In With Your Injector Regularly
If you already get filler or wrinkle relaxers, consider scheduling reassessment appointments every few months. As facial fullness decreases with weight loss, fillers may sit slightly differently.
If you notice that your Botox isn’t lasting as long as it used to, ask your provider if it’s worth switching to a different brand. Some women respond better to alternatives like Dysport, Xeomin, or Daxxify.
2. Prioritize Skin Hydration—Inside and Out
Keeping your skin hydrated and supported during this time can help you maintain that healthy, radiant glow.
- Drink plenty of water: Aim for half your body weight in ounces per day. Dehydration can make skin look dull or tired, especially during weight loss.
- Use supportive skincare: Hyaluronic acid-based serums or moisturizers can help maintain skin elasticity.
- Keep it consistent: A gentle, hydrating skincare routine, paired with daily SPF, goes a long way when your body is adjusting.
3. Monthly Facial Massages to Stimulate Collagen
Facial massages are a relaxing way to boost collagen production and improve skin elasticity. Techniques like gua sha or manual lymphatic drainage are believed to help increase blood flow, which delivers nutrients to skin cells and may help counteract the thinning and sagging that can occur with rapid weight loss.
For best results, use a hydrating serum (look for hyaluronic acid or peptides) to reduce friction and enhance absorption.
4. Expect Natural Definition Changes
Some areas, such as the jawline, under the chin, or temples, may appear more contoured as weight comes off. If you’ve had filler in those areas before, it might simply look different now. That’s not a problem—it’s a natural shift that your provider can adapt to with subtle touch-ups if needed.
Supporting Your Look Through Every Phase
Your body is changing in a beautiful way, and it’s completely normal for your aesthetic routine to shift with it. Whether you’re refreshing filler, adjusting wrinkle relaxers, or just being mindful about hydration and skincare, small updates can help you feel just as good in the mirror as you do in your clothes.
Feel Your Best Inside and Out with PeachesRx
At PeachesRx, we’re proud to support women through every stage of their weight loss journey. Our compounded semaglutide oral dissolving tablet, Slim, offers a convenient, injection-free way to lose weight, designed to fit seamlessly into your everyday life.
If you’re ready to explore whether Slim could be the right fit for you, visit peachesrx.app to see if you qualify.
